search is needed to confirm this hypothesis. Arrows indicate example active caspase-3–positive cells. In children with CRS who have failed medical therapy, a stepwise approach to surgical intervention can lead to significant improvements in quality of life. Ces démarches de relogement sont justifiées et c’est un boulot de fou. Les logements destinés à remplacer un immeuble détruit prennent en effet des années à sortir, rallongeant d’autant les listes d’attente. This was probably because the culture medium prevented the exchange of oxygen as the tissue outside the cylinder that was exposed to oxygen was in perfect condition (figure 3A in online supplement). Les démolitions peuvent ainsi provoquer un effet de goulot d’étranglement : dans l’opération de relogement de l’UC1, 55 % des habitants sont restés sur Bron, les autres ont bougé dans une commune limitrophe. Brown, in Advances in Virus Research, 2018. In CRS patients, both with and without nasal polyps, the expression levels of HNE, LC3B, JNK, c-Jun, and MUC5AC were upregulated. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. " total destruction of a Raymond excur sion train. Le quartier de Parilly est créé, constitué de huit unités de construction (UC). Our findings indicate that Smad4 is a pre-requisite for providing stability to ATF3 via TGF-β1 in human breast cancer cells. (C) TUNEL (green) and cytokeratin (red) double staining of a colitis specimen (referred to as UC1). Après, tout dépend de la capacité des habitants à refaire leur vie. Compared with the ex vivo controls, in CRSwNP, the levels of TGF-β1, collagen I, pSmad2/Smad3, Smad2, and Smad3 were markedly decreased after relaxin-2 treatment. Prochaine cible : la barre 6A qui pourrait, si l’ANRU donne son feu vert, « tomber » dans les dix ans. Et je mangeais trois ou quatre fois… En face du Grand Frais vous trouvez un sikh avec un turban, un bonze avec sa toge orange et des papys-mamys chibanis qui se font la bise. However, at present, the research on mucin is mainly focused on mucin 5AC and mucin 5B, which is bad for finding new therapeutic targets. Les experts de l'époque prédisent même que le seuil des 100.000 habitants serait atteint vers l'an 2000 ! The antifibrotic effects of relaxin-2 may play a role in tissue remodeling in CRSwNP, but the detailed mechanism deserves further study. By learning more about species like sea turtles, you are on your way towards helping protect animals in your own backyard and beyond! The phenotype of CRS affects the expression of various mucins, especially in nasal polyps (NP). The train, which consisted of palace cars. In ASPNet webforms - everything needs to run within a form tag. Ces démolitions permettront de recomposer le quartier, de construire des petits collectifs de logements adaptés à la demande et de réaliser des aménagements paysagers. ].Goblet cells in the superficial epithelium, ]. State Archives Open By Appointment Only. Springer Nature journal, content cannot be used for inter-library loans and librarians may not upload Springer Nature journal content on a large scale into their, or any, These terms of use are reviewed regularly and may be amended at any time. A promoter for TGF-β2 and TGF-β3 isoforms possesses in its structure a classical TATAA box domain and a CRE-ATF terminal region. SOG2 protein super family participates in RAM signaling pathway within the, Diagrammatic presentation of conserved domains of MUC2, MUC6, MUC5AC, and MUC5B. Springer Nature is not obligated to publish any information or, content on this website and may remove it or features or functionality at our sole discretion, at any time with or without notice. Il y a une inquiétude parfois, bien sûr. D’où la nécessité de démolir, et donc déraciner, avec parcimonie. Alors que dans le même temps, Retourner à l'accueil de Tribune de Lyon, Déposer une annonce légale dans Tribune de Lyon. from one disease to different phenotypes. Neonatal capsaicin-treated rats cause destruction of small primary afferent neurons [9]. Histopathology of polyp apex had good sensitivity for diagnosing EMRS. The secondary structures of mucins vary greatly in length, number, domain, and VNTR (variable number tandem repeat) domain. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. C’est ainsi un bout d’histoire de Bron et de l’urbanisme français qui va être grignoté lentement de l’intérieur : douches, baignoires, portes, lavabos, tuyauterie… seront arrachés aux entrailles délabrées de l’UC1, avant que la structure elle-même ne soit non pas explosée, mais croquée progressivement à coups de machines. Scientifically trained, … purposes, Springer Nature considers academic use (by researchers and students) to be non-commercial. Previous, a decrease in the expression of both MUC5AC and, MUC5B in human bronchial epithelial cells. 1654 – Arauco War: A Spanish army is defeated by local … Eosinophil/neutrophil counts were obtained from histopathologic slide review. Polyp pedicle and ethmoid mucosal eosinophilia associated with asthma. The full text articles selected were then categorized into 3 study groups: (1) clinical, (2) animal, and (3) in vitro cultures. Ce serait dur de tenir l’immeuble pendant un hiver encore. found that the neutrophil type cells accounted for 8%. Evidemment, ce n’est pas le monde des bisounours. Due to the exploratory methodology, positive results may be spurious and should only be used as a starting point for future confirmatory work. There is a strong correlation between alterations in mucin expression profiles and CRS. Sans oublier que les solutions les plus dures à trouver sont celles destinées aux familles. Rights reserved. The number of macrophages (CD68(+) cells), IL-17A, and MUC5AC(+) cells in ECRS were significantly greater than in non-ECRS. Purpose of review: Sensitivity for diagnosing EMRS were 100% (95%CI: 47.8 - 100) for polyp apex, 60% (95%CI: 14.7 - 94.7) for polyp pedicle, 80% (95%CI: 28.4 â€" 99.5) for ethmoid mucosa. Anouck Patriarche, ethnologue et biographe a, pendant huit mois, rencontré une trentaine de locataires de la barre UC1. ». HNE induces MUC5AC, 2 genes were regulated by miR-532-3p and miR-, 1 stimulates the differentiation of fibroblasts, he differentiated myofibroblasts increase, 1 is considered to be an important factor for MUC5AC, ], especially regulating mucus hypersecre-, can enhance collagen synthesis during tissue remod-, compared with healthy individuals, whereas patients with, ] demonstrated that the decrease of expression, 1 may be associated to the edema formation in, 1 concentration, mRNA expression, and the number of, ]. decrease major secreted mucins (MUC5AC and MUC5B). À partir de cette date, les deux voies qui traversent le quartier entre arbres et ronds-points deviennent le périphérique Laurent-Bonnevay et l’autoroute A43. Ex vivo NP were treated with relaxin-2 (n = 15) or TGF-β1 (n = 15). Neither the numbers of neutrophils (positive cells for neutrophil elastase) nor the IL-8(+) cells showed any significant differences between ECRS and non-ECRS. Background: The aim of this study was to evaluate and compare mucin gene expression at epithelial and glandular, Recently, some researchers have reported that macrophages and neutrophils were related to severe asthma. Cultures are indicated in patients who have not responded to medical therapy or have significant comorbidities. and, being north of the River Avon, then falls within the Saxon petty-kingdom of the Hwicce. Dans le recueil de témoignages, souvent un fil rouge se dégage : à Vaulx-en-Velin, c’était les chibanis (anciens travailleurs immigrés maghrébins, NDLR) qui avaient construit Lyon. eling by downregulating the TGF-beta3 isoform in house dust, pression in the tissue remodeling involved in chronic, understanding of the role of IgE 'above atopy'. Chromatin immunoprecipitation was then used to identify the formation of an ATF3 and Smad4 complex at the matrix metalloproteinase 13 (MMP13) promoter upon TGF-β1-treatment, and the knockdown of Smad4 decreased MMP13 promoter activity in MDA-MB231 cells. It is important to identify which mucin gene messenger RNAs (mRNAs) are expressed in the sinus mucosa. David Hunter Strother (September 26, 1816 – March 8, 1888) was an American journalist, artist, brevet Brigadier General, innkeeper, politician and diplomat from West Virginia.Both before and after the American Civil War (in which he was initially a war correspondent), Strother was a successful 19th century American magazine illustrator and writer, popularly known by his pseudonym, "Porte Crayon" … Much like SBV, CBPV can exert … levels, and to identify potential mucin expression patterns for specific upper airways pathologies. MicroRNAs regulating mucin type O-glycan biosynthesis and. and many pro-inflammatory cytokines regulate goblet cell, ble for many of the manifestations and symptoms of CRS, Most scholars believed that hyperplasia and metaplas, Current Allergy and Asthma Reports (2020) 20: 63. Le 18 septembre, la Ville présentait justement, devant le comité d’engagement de l’agence, son plan guide pour la suite du renouvellement du quartier. Mucus hypersecretion and persistent airway inflammation result from increased expression of mucin gene (MUC5AC). Le dernier programme de rénovation urbaine ANRU a permis la démolition en 2008 de l’UC 7, une « virgule » de 378 logements qui a laissé la place, non loin, à la médiathèque Jean-Prévost et à un total de 159 logements dont 60 sociaux, 39 en locatif privé et 60 en accession abordable. Spearman correlations between cytokines, cell counts, and quality-of-life subdomain scores were assessed without multiple comparisons correction due to the small sample size. Methods infiltrating macrophages, neutrophils, their promotive factors, and MUC5AC. In addition, TGF-β1 binds to receptor TGFβ-IIR and activates Smad signal transduction pathway. Bron devenait une ville importante de la banlieue lyonnaise. (PKC: protein kinase C; PAR2, protease activated receptor 2; TACE, TNF-α converting enzyme; EGFR: epidermal growth factor receptor; MARCKS, myristoylatde alanine-rich C kinase substrate), TGF-β participates in the regulation of airway inflammation and remodeling process. Tissue samples were analyzed by Masson trichrome staining for collagen, while the location and expression of relaxin-2, transforming growth factor beta 1 (TGF-β1), and phosphorylated (p) Smad2/Smad3 were analyzed by immunohistochemistry and Western blot. C’est lui qui a piloté l’opération de relogement de l’UC1 (unité de construction numéro 1, NDLR). Deux énormes aménagements routiers arrivés bien après ce grand ensemble, construit entre 1956 et 1964, fierté de la ville d’alors. decrease major secreted mucins (MUC5AC and MUC5B). This review highlights the expression and regulation of mucin in CRS and discusses its clinical implications. Recent findings: C’est très déstabilisant, extrêmement traumatisant pour les personnes âgées. Please note that these rights do not automatically extend to content, data or other material published by Springer Nature that may be licensed, If you would like to use or distribute our Springer Nature journal content to a wider audience or on a regular basis or in any other manner not, expressly permitted by these Terms, please contact Springer Nature at. dle meatal cytokine levels correlate with olfactory function in, Soler ZM. Methods: Diagrammatic presentation of conserved domains of MUC2, MUC6, MUC5AC, and MUC5B. to human chromosome 7q22. Background: Il faut arriver à recréer des liens ailleurs. La fin de ce paquebot de 330 logements créé en 1959 prolonge la déconstruction de Parilly, un des plus grands ensembles de son époque, qui a logé jusqu’à 2 500 familles. i Humbert tf New … Springer Nature journal content, brought to you courtesy of Springer Nature Customer Service Center GmbH (“Springer Nature”). 1944 - September: greatest destruction of the city centre and the port during bombings of the British Royal Air Force, more than 5,000 dead (Operation Astonia). L’UC1 se prépare à sa démolition Bron - Urbanisme L’UC1 se prépare à sa démolition La barre longeant le boulevard périphérique devrait être détruite à l’horizon 2018. Comment comprendre tant de nostalgie dans les relogements d’une barre difficile ? Salou, 32 ans, installé à l’UC1 depuis ses années d’université, a joué la carte de la patience pour être relogé à Lyon. The results, showed that the expression intensity and dis, expression of mucin in the ethmoid mucosa of 8 patients with, CRS. 1766 Thomas Brown, 1740-1799. Letters to Dr. Priestley David Levi and 1733-1804. Letters to the Jews Joseph Priestley. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. This suggests that the most significant variations of, reverse transcription polymerase chain reaction and immuno-, histochemistry to detect the expression and distribution of, MUC8 in the maxillary sinus mucosa in CRS. Mais elle contraint aussi à construire autant de logements aidés qu’il en a été supprimé, sur la commune ou une ville limitrophe. Results: In total, aberrant expression of 8 mucins—6 secreted-mucins (MUC2, -5AC, -5B, -6, -7, and -8) and 2 membrane-bound mucins (MUC1 and -4)—were identified in CRS tissues compared to healthy controls. – Jim "Entropy" Brown. There was a significant correlation in all cases between IL-17A and macrophages or MUC5AC(+) cells. component in sinus mucins while MUC5B and MUC2 predominated in normal nasal mucin. « Il n’y pas de dead line au calendrier, mais une volonté de faire vite », concède Paul-Antoine Lacombe. Alors que la tour 7 est tombée et que la chute de la 6A est envisagée, Bron tente aujourd’hui de conjuguer mixité, dédensification et maintien du logement social. changes in CRS. This review provides an overview of the current guidelines and recent literature regarding the diagnosis, microbiology, and treatment options of CRS in the pediatric population. Our goal in this systematic review was to determine (1) expression profiles, (2) regulatory mechanisms, and (3) the pathologic roles of mucins associated with CRS. Il ne reste aujourd’hui plus que 17 familles à reloger. 1958 - Le Havre City Hall rebuilt. transactivation promoter activity in a sy, have shown that MAPK14 phosphatase-1-dependent in-, hibitor can act as a negative regulator of MUC5AC, MUC5AC expression is also controversial. Goulot d’étranglement dans le relogement. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. Mucins (MUCs) are important components of secreted mucus, mucin (MUC)5 AC is the major MUC secreted in the normal airway. (VWD, von Willebrand factor (vWF) type D domain; WxxW, WxxW repeating region; C8, This domain contains 8 conserved cysteine residues; TIL, trypsin inhibitor-like cysteine rich domain; VWC, von Willebrand factor type C domain; Cy-Knot, cystine-knot domain; CT, C-terminal cystine knot-like domain (CTCK)), Diagrammatic presentation of tertiary structures of MUC2, MUC6, MUC5AC, and MUC5B. The diagnosis of pediatric CRS is primarily based on clinical history and signs supported by objective findings (i.e., nasal endoscopy and/or computed tomography (CT) imaging). J Allergy Clin Immunol. Pas de « big bang » en bordure de périph’. Results Inhibitor in, the expression of ECM components (such as fibronectin and. The history of the destruction of the city and temple of Jerusalem, and of the ruin and dispersion of the Jewish nation : to which is added Dr. Priestley's letters to the Jews, and an answer by David Levi . L’âge joue aussi. Springer Nature. However, the relationship, between the efficacy of oral corticosteroids and the expression of, MUC1, as well as the possible interactions among corticostero, erone complex. Rhinology. Corticosteroids(CS), human neutrophil elastase (HNE), and transforming growth factor-β1 (TGF-β1) are closely related to the tissue remodeling of CRS and regulate mucin expression, mainly MUC1, MUC4, MUC5AC, and MUC5B. », Mais en ce début d’été, le temps presse. Sur les 330 logements détruits de l’UC1, 247 seront reconstruits à Bron. mon mediator Smad3, and inhibitory mediator Smad724. Chronic bee paralysis virus (CBPV) is an intriguing RNA virus because its genome consists of two separate positive-stranded RNA molecules. Although many reported studies, in lower respiratory tract diseases, the relationship is still unclear, inflammatory cells and permeate in the bronchial mucosa, from regulatory T cells (Tregs) is related, affects Tregs but also destroys the integrity of Tregs in, profibrotic cytokine and a major stimulator of fibroblast activa-, tion, which can induce activation and differentiation of fibro-, has collagen contractile activities and can initiate tissue remodel-, signaling acts as a negative regulator via MAPK14. Mucous cytokine levels in chronic rhinosinusitis-, regulation of MUC5AC and MUC5B mucin genes in chronic, ulation of ATP-dependent MUC5AC gene expression. The phenotype of CRS affects the expression of various mucins, especially in nasal polyps (NP). Sur Bron, ça “ tire ” », prévient Jean-Michel Longueval. 1569 – First recorded lottery in England. C’est compliqué à chauffer. Inscrit partiellement à l’inventaire supplémentaire des…, Le conseil municipal de Lyon s’est engagé jeudi à réaliser 1 559 logements sociaux par an d’ici 2022, espérant même atteindre le seuil symbolique des 2 000, avec l’objectif d’atteindre les 25 % imposés par la loi SRU d’ici 2025 contre 21,5 % aujourd’hui. SOG2 protein super family participates in RAM signaling pathway within the scope of MUC5AC protein WxxW repeating region. To the fullest extent permitted by law, Springer Nature makes no warranties, representations or guarantees to Users, either express or implied. However, in the normal sinus mucosa, MUC5AC and MUC5B proteins were expressed at low levels in the sinus epithelium and submucosal glands, respectively. 1055 – Theodora is crowned empress of the Byzantine Empire. Ti2000 has a high strength, high-performance suspension coil, and high-performance suspension coil has achieved high-performance suspension coil-indispensable high strength, high-performance, high strength, high-performance suspension coil, and high-performance … Juste une lente métamorphose. Le temps du village était révolu. Allergy. By, accessing, sharing, receiving or otherwise using the Springer Nature journal content you agree to these terms of use (“Terms”). Descendre sous les 25 % contraindrait la Ville à s’acquitter d’amendes. It was agreed that the best way to address these was to conduct a Delphi exercise . Il y a quand même des quartiers qui ont besoin de se dédensifier : l’UC1 est agglutinée au-dessus du périph’, c’est impossible d’ouvrir la fenêtre. According to the existing, results, we find that MUC5AC is distributed in epithelial goblet, cells and SMG, MUC5B is distributed in SMG, and the distri-, bution of other mucins needed further study, mucin depends on various inflammatory factors. Collagen type I (collagen I), relaxin-2, and TGF-β1 levels in the culture supernatants were examined by enzyme-linked immunosorbent assay, while pSmad2/Smad3 in culture pellets was analyzed by Western blot, and the expression of Smad2 and Smad3 mRNA was tested by qPCR. Mais à Bron, je n’avais jamais vu autant de nationalités différentes : 30 en 35 entretiens ! Au fil du temps, l’UC1 s’est vidée, a été squattée, la proie des trafics. Mode of access: Internet Topics: Christianity, Judaism, Jews . Primary HNECs were treated with HNE, bafilomycin A1, and SP600125. Parilly. This pilot study identifies possible pairwise correlations between mucus cytokine levels and baseline quality-of-life measures that need confirmation in larger, targeted studies. The full document can be downloaded for free on the website of this journal: Results reduces the recovery of the template units. The collagen, relaxin-2, TGF-β1, and pSmad2/Smad3 protein expression levels were significantly decreased in the CRSwNP group compared with the CRSsNP group ( P < .05). 1571 – Austrian nobility is granted freedom of religion. MUC5AC and MUC5B represent a major, Excess mucus production and hypersecretion characterize upper airway diseases. MUC1, MUC4, and MUC5AC mucins were highly expressed in the epithelium and their expression pattern was similar in all NP types, MUC1 and MUC4 being increased and MUC5AC decreased compared with NM. Localization of these proteins was sought by using immunohistochemical analysis. Abstract. proteins and are anchored to the apical surface of mucosal, reported in the upper airways. « Il y a une dame qui ne répond pas. Conclusions However, MUC2, MUC5AC, MUC5B, MUC7, and MUC8 were the major mu-, cins in the ethmoid mucosa. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. exocyst complex regulates mucin 5AC secretion induced by. » En ce début juillet, Paul-Antoine Lacombe, directeur d’agence chez Lyon Métropole Habitat, se sent un brin désarmé. On n’y échappe pas, et évidemment je m’oppose à toute vente massive de logements sociaux. 2.8 Chronic Bee Paralysis Virus. At least 3 mucins are expressed at various levels in chronic sinusitis. C’est un truc de fou. « On m’a d’abord proposé d’aller … (B) Active caspase-3 (brown) staining of a matched pair of uninvolved colonic and colitis tissues from a patient with UC (original magnification, ×400). Methods: In miR-32-3p, miR-548e-3p, and, miR-3149 miRNAs, miR-548e-3p is the only miRNA involved, 500a5p, and miR-548e-3p are the three most important, primarily by the Smad proteins: receptor-mediated Smad2, com-. The results showed that the location of 8, mucins is in nasal polyps, which demonstrated that more mucin. Trough plasma concentrations of BAY 85-8501 plateaued after 2 weeks. In addition, HNE can make MARCKS phosphorylation to activate MUC5AC, concentration and PKC induces MUC5AC secretion in Calu-3, expression in airway epithelial cells via tumor necrosis factor-, Recent clinical observational studies also suggested that HNE, is a key risk factor for the onset and persistence of bronchiectasis, with CRS and nasal polyp. Créé en 2005, ce magazine indépendant est édité par la société indépendante Rosebud, principalement détenue par ses salariés. (VWD, von, in CRS. Little is known about its impact on chronic rhinosinusitis with nasal polyps (CRSwNP); thus, we aimed to determine the expression of human H2 relaxin (relaxin-2) and its role in tissue remodeling in CRSwNP. In NM, MUC6 and MUC7 were scarcely detected and MUC7 expression was restricted to glands. The expression of relaxin-2, Smad2, Smad3, and TGF-β1 mRNA in the CRSsNP group was significantly higher than in the CRSwNP and control groups ( P < .05). Short course of systemic corticosteroids in sinonasal. Background: However, the mechanism behind the stability of ATF3 expression is not yet known. Autophagic vacuoles were studied using transmission electron microscopy (TEM). © 2008-2020 ResearchGate GmbH. 1968 - Le Havre presse newspaper in publication. Par choix, le plus souvent, mais pas uniquement. reactive oxygen species. La démolition de la barre no 1 surplombant le périphérique Laurent-Bonnevay démarre cet automne. including merchantability or fitness for any particular purpose. In some experiments, cultured primary HNECs were transfected with small interfering RNAs (siRNAs) to target Beclin-1 (BECN1; BECN1-siRNA), autophagy-related gene 5 (Atg5; Atg5-siRNA), and c-Jun (c-Jun-siRNA). Three TGF-β isoforms have been found in the human body, respectively: TGF-β1, TGF-β2, TGF-β3.TGF-β1, TGF-β2, and TGF-β3 are localized on chromosomes 19q13, 1q41 and 14q24, respectively. A summary for otorhinolaryngologists. The expression of 3 airway mucins, MUC2, MUC5AC, and MUC5B, was determined by ELISA. However, in . Purpose of Review And more mucin genes are, MUC8 in normal nasal mucosa. Relationships between IL-17A and Macrophages or MUC5AC in Eosinophilic Chronic Rhinosinusitis and Pr... Access to this full-text is provided by Springer Nature. The analysis of these studies is limited by the heterogeneity in study designs, relatively few numbers of clinical samples, and lack of mechanistic studies in animal models and in vitro cultures. There Is no authentic news as to the lots of life.. . ' MEDLINE, Cochrane Library, Embase, Scopus, Web of Science, and were searched for studies focused on the role of mucins in CRS. But the function of this region is unknown and the repetitive sequence can be present in up to 32 copies. For these. Immunohistochemistry for MUC1, MUC2, and MUC4-MUC8 mucins was performed on healthy nasal mucosa (NM; n=12), bilateral nasal polyps (NP; n=38), NP from CF patients (n=10), and antrochoanal (AC) polyps (n=11). Un bout de 90 logements environ de la barre 6A, entre la rue Paul-Pic et l’A43, est démoli afin d’améliorer la transition entre les UC6A et B et le quartier pavillonnaire voisin. Results: On sait qu’elle est là, mais elle vit quasiment cloîtrée et n’ouvre pas quand on toque à la porte. We examined 21 nasal polyps with CRS. Background: For more information about scheduling an appointment, send an email to or give us a call at 317-591-5222. Relaxin is a small peptide hormone that regulates extracellular matrix remodeling and reduces fibrosis in a number of organs. Et je n’en ai vu que 35 sur 380. Ce ne serait pas raisonnable. Le sud de Parilly sera également concerné avec une réhabilitation importante des UC2 et UC3. However, aberrant expression of mucins is associated with mucus hypersecretion resulting in chronic nasal drainage, a common complaint from patients with chronic rhinosinusitis (CRS). 2015;70(5): nasal polyps 2012. Investigating the expression and location of mucin in nasal mucosa and understanding the role of various inflammatory factors in mucin expression are helpful to figure out regulatory mechanisms of airway mucin hypersecretion.